In enzymology, an arachidonate—CoA ligase (EC 6.2.1.15) is an enzyme that catalyzes the chemical reaction

ATP arachidonate CoA ⇌ {\displaystyle \rightleftharpoons } AMP diphosphate arachidonoyl-CoA

The 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is arachidonate:CoA ligase (AMP-forming). This enzyme is also called arachidonoyl-CoA synthetase.

References

  • Wilson DB, Prescott SM, Majerus PW (1982). "Discovery of an arachidonoyl coenzyme A synthetase in human platelets". J. Biol. Chem. 257 (7): 3510–5. PMID 7061494.



Andy Howard Biochemistry Lectures, Spring April ppt download

Succinatecoa ligases; succinylcoa synthetases

The step catalyzed by 4coumarate CoA ligase (4CL) toward the

Figure 2 from Application of an AcylCoA Ligase from Streptomyces

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